83,201 skills sorted by stars.
Evaluate research rigor. Assess methodology, experimental design, statistical validity, biases, confounding, evidence qu...
评估研究严谨性。用于评估方法学、实验设计、统计学有效性、偏倚、混杂因素以及证据质量（如 GRADE、Cochrane 偏倚风险评估），以对科学结论进行批判性分析。
Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code...
⚠️ CRITICAL USER EXPERIENCE-BASED SKILL - ALWAYS CONSULT BEFORE DATA PREPROCESSING ⚠️ Prevents catastrophic errors (88.9...
Work with Data Commons, a platform providing programmatic access to public statistical data from global sources. Use thi...
Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery inc...
Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, a...
Efficient database search tool for bioRxiv preprint server. Use this skill when searching for life sciences preprints by...
Query ChEMBL's bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivi...
Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial detail...
Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele func...
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications,...
Access COSMIC cancer mutation database. Query somatic mutations, Cancer Gene Census, mutational signatures, gene fusions...
Access and analyze comprehensive drug information from the DrugBank database including drug properties, interactions, ta...
Access European Nucleotide Archive via API/FTP. Retrieve DNA/RNA sequences, raw reads (FASTQ), genome assemblies by acce...
Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identificat...
Query NCBI Gene via E-utilities/Datasets API. Search by symbol/ID, retrieve gene info (RefSeqs, GO, locations, phenotype...
Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-value...
Access Human Metabolome Database (220K+ metabolites). Search by name/ID/structure, retrieve chemical properties, biomark...
Direct REST API access to KEGG (academic use only). Pathway analysis, gene-pathway mapping, metabolic pathways, drug int...
Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/o...
Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/s...
Direct REST API access to PubMed. Advanced Boolean/MeSH queries, E-utilities API, batch processing, citation management....
科学调试专家 - 观察(Observe) -> 假设(Hypothesize) -> 实验(Experiment) -> 修复(Fix)
Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditi...
NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for...
Multiagent AI system for scientific research assistance that automates research workflows from data analysis to publicat...
Diffusion-based molecular docking. Predict protein-ligand binding poses from PDB/SMILES, confidence scores, virtual scre...
Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence,...
Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI...
Perform comprehensive exploratory data analysis on scientific data files across 200+ file formats. This skill should be...
Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to C...
Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations includi...
Generate or edit images using AI models (FLUX, Gemini). Use for general-purpose image generation including photos, illus...
This skill should be used when working with genomic interval data (BED files) for machine learning tasks. Use for traini...
Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retr...
Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when wor...
Fast CLI/Python queries to 20+ bioinformatics databases. Use for quick lookups: gene info, BLAST searches, AlphaFold str...
High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regio...